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Synthesis of 5‑Aryl-3(2H)‑furanones Using Intramolecular Cyclization of Sulfonium Salts

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posted on 2018-10-31, 00:00 authored by Sho Inagaki, Kai Saito, Soichiro Suto, Hiromi Aihara, Aoi Sugawara, Satoru Tamura, Tomikazu Kawano
Base-induced intramolecular cyclization of novel (4-aryl-2,4-dioxo­butyl)­methyl­phenyl­sulfonium salts prepared from the commercially available 1-arylethanone by a cost-effective process is described in this paper. The reaction was completed within 10 min to produce a family of 2-unsubstituted 5-aryl-3­(2H)-furanones in excellent yield. This procedure is simple, and can be carried out under mild conditions and an ambient atmosphere.

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