Synthesis of 4-acetyl-2(3<i>H</i>)-benzothiazolone: Sulfur bioisostere of benzoxazolone allelochemicals

<p></p> <p>A multi-step methodology for the synthesis of 4-acetyl-2(3<i>H</i>)-benzothiazolone was developed in order to prepare a new biomimetic analogue of benzoxazolone allelochemicals. The compound was prepared from commercially available <i>o</i>-toluidine in 23% overall yield. The structure of 4-acethyl-2(3<i>H</i>)-benzothiazolone was confirmed by NMR spectroscopy and X-ray crystallography.</p>