Synthesis of 4-acetyl-2(3H)-benzothiazolone: Sulfur bioisostere of benzoxazolone allelochemicals

Gerova, Mariana S.; Svetoslavov, Filip E.; Shivachev, Boris L.; Nikolova, Rositsa P.; Petrov, Ognyan I.

doi:10.6084/m9.figshare.5198485.v1

gpss_a_1321645_sm1382.docx (1.63 MB)

Synthesis of 4-acetyl-2(3H)-benzothiazolone: Sulfur bioisostere of benzoxazolone allelochemicals

journal contribution

posted on 2017-07-12, 14:23 authored by Mariana S. Gerova, Filip E. Svetoslavov, Boris L. Shivachev, Rositsa P. Nikolova, Ognyan I. Petrov

A multi-step methodology for the synthesis of 4-acetyl-2(3H)-benzothiazolone was developed in order to prepare a new biomimetic analogue of benzoxazolone allelochemicals. The compound was prepared from commercially available o-toluidine in 23% overall yield. The structure of 4-acethyl-2(3H)-benzothiazolone was confirmed by NMR spectroscopy and X-ray crystallography.