Synthesis, characterization, X-ray crystal structures, and antibacterial property of oxidovanadium(V) complexes with halide-containing hydrazones

Two oxidovanadium(V) complexes, [VOL¹(OMe)(MeOH)] (1) and [VOL²(OEt)(EtOH)] (2), where H₂L¹ = 4-bromo-N’-(3,5-dibromo-2-hydroxybenzylidene)benzohydrazide and H₂L² = 4-bromo-N’-(3,5-dichloro-2-hydroxybenzylidene)benzohydrazide, have been synthesized by reaction of VO(acac)₂ with the hydrazone ligands and characterized by elemental analyses, IR, UV-Vis, molar conductivity, and X-ray single-crystal structural determination. The hydrazone ligands coordinate to the V atoms through phenolate oxygen, imino nitrogen, and enolate oxygen atoms. The V atoms are in octahedral coordination, with the other three sites furnished by one methanol or ethanol oxygen, one deprotonated methanol or ethanol oxygen, and one oxido group. The antibacterial property of the complexes and the hydrazones against the bacteria Bacillus subtilis, Escherichia coli, Pseudomonas putida, and Staphylococcus aureus were studied. Both complexes exhibit remarkable antibacterial properties on B. subtilis and S. aureus comparable to Penicillin.