gnpl_a_1484459_sm1508.pdf (1.02 MB)
Synthesis and biological evaluation of C-13, C-14 modified taxane analogues from 1-deoxybaccatin VI
journal contribution
posted on 2018-06-13, 14:09 authored by Ping Tang, Hai-Xia Lin, Tian-Hai Yuan, Yong-Mei CuiFour C-13, C-14 side chain modified 9(R)-hydroxy-1-deoxy-taxane analogues 15, 16, 19 and 22 were semi-synthesized from 1-deoxybaccatin VI. The in vitro antitumor activity of these compounds was evaluated against A549 and A2780 cell lines. The preliminary SAR analysis showed that introduction of oxygen-containing group on C-14 could improve the cytotoxic activities.