Synthesis and biological evaluation of C-13, C-14 modified taxane analogues from 1-deoxybaccatin VI

<p>Four C-13, C-14 side chain modified 9(<i>R</i>)-hydroxy-1-deoxy-taxane analogues <b>15</b>, <b>16</b>, <b>19</b> and <b>22</b> were semi-synthesized from 1-deoxybaccatin VI. The <i>in vitro</i> antitumor activity of these compounds was evaluated against A549 and A2780 cell lines. The preliminary SAR analysis showed that introduction of oxygen-containing group on C-14 could improve the cytotoxic activities.</p>