Synthesis and Biological Evaluation of Hippolachnin A Analogues

The marine polyketide hippolachnin A (1) has attracted considerable attention from synthetic chemists due to both its intricate core structure and attractive biological activity against virulent fungi. Described herein are recent efforts to employ our recently developed synthesis in structure–activity relationship studies of 1. These studies have revealed that, in contrast to initial reports, 1 and several structural analogues lack activity against pathogenic fungi.