Synthesis and biological activity of ethyl 2-(5-methyl-3-arylisoxazole-4-carboxamido)-4-alkylthiazole-5-carboxylate

<p>A series of novel ethyl 2-(5-methyl-3-arylisoxazole-4-carboxamido)-4-alkylthiazole-5-carboxylates <b>I-1</b>-<b>6</b> were synthesized. The structures of all target compounds were characterized by <sup>1</sup>H NMR, <sup>13</sup>C NMR, IR, MS and elemental analyses. Their fungicidal and herbicidal activities were evaluated. The results of preliminary bioassays show that the title compounds <b>I-4</b> possess 20–50% inhibition against most of the tested plants at the dosage of 150 g ai/ha, while the title compounds <b>I-1-5</b> possess 32–58% inhibition against <i>FusaHum graminearum, Thanatephorus cucumeris, Botrytis cinereapers</i> and <i>Fusarium oxysporum in vitro</i> at the concentration of 100 mg/L.</p>