ienz_a_1337758_sm5053.pdf (725.05 kB)
Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents
journal contribution
posted on 2017-06-29, 14:14 authored by Serdar Burmaoğlu, Hatice Seçinti, Erkan Mozioğlu, Ahmet C. Gören, Ramazan Altundaş, Hasan SeçenFour multicaulin and miltirone-like phenanthrene derivatives were synthesised and evaluated as antituberculosis agents. The crucial step of the synthesis was Pschorr coupling of 4-(3-isopropyl-4-methoxyphenyl)-2-(2-aminophenyl)ethane (13) to give 2-isopropyl-3-methoxy-9,10-dihydrophenanthrene (9) and 4-isopropyl-3-methoxy-9,10-dihydrophenanthrene (9a). Compound 9 was converted to multicaulin and miltirone-like phenanthrene derivatives by further reactions. The best antituberculosis activity was exhibited by 2-isopropylphenanthrene-3-ol (11).