Supplementary Material for: Impact of Hybrid Therapy Comprising Peritoneal Dialysis and Hemodialysis on Acute Cardiovascular Events

<b><i>Background:</i></b> The impact of hybrid therapy comprising peritoneal dialysis (PD) and hemodialysis on cardiovascular events in PD patients remains unclear. <b><i>Objective:</i></b> We aimed to evaluate the effect of hybrid therapy on cardiovascular events. <b><i>Methods:</i></b> A total of 93 PD patients undergoing hybrid therapy for ≥3 years were divided into 2 groups according to left ventricular ejection fraction (LVEF): lower ejection fraction (LEF [<i>n</i> = 29], LVEF < 60%) and normal ejection fraction (NEF [<i>n</i> = 64], LVEF ≥60%). Hospitalization rates and echocardiographic parameters were evaluated. <b><i>Results:</i></b> The 1-year hospitalization rate for acute cardiovascular events decreased after the therapy initiation in both groups (LEF: 0.36–0.11, <i>p</i> = 0.02 and NEF: 0.43–0.06, <i>p</i> < 0.001). In generalized linear mixed models, LVEF (44 ± 15%) improved at 1, 2, and 3 years after initiation (53 ± 18, 55 ± 17, and 58 ± 7%; <i>p</i> < 0.05) in the LEF group, whereas, in the NEF group, LVEF (68 ± 5%) was maintained at 1, 2, and 3 years after initiation (67 ± 8, 67 ± 9, and 68 ± 9%; <i>p</i> > 0.05). Mitral inflow E velocity to tissue Doppler e′ ratio was maintained at the same level at 1–3 years after initiation in both groups. Left ventricular mass index (LVMI; 189 ± 41 g/m<sup>2</sup>) was decreased at 1 (178 ± 35 g/m<sup>2</sup>; <i>p</i> = 0.8), 2 (160 ± 45 g/m<sup>2</sup>; <i>p</i> = 0.008), and 3 (166 ± 47 g/m<sup>2</sup>; <i>p</i> = 0.05) years after initiation in the LEF group, whereas in the NEF group, LVMI (157 ± 45 g/m<sup>2</sup>) was maintained at 1, 2, and 3 years after initiation (153 ± 40, 155 ± 54, and 158 ± 52 g/m<sup>2</sup>; <i>p</i> > 0.05). <b><i>Conclusion:</i></b> Hybrid therapy decreased acute cardiovascular events and improved systolic cardiac function in PD patients in the LEF group.