Supplementary Material for: Efficacy and Safety of Topical Pidobenzone 4% as Adjuvant Treatment for Solar Lentigines: Result of a Randomized, Controlled, Clinical Trial

<strong><em>Background/Objective:</em></strong> This study aims at the evaluation of the efficacy and safety of a combination therapy based on pidobenzone 4% and fractional CO<sub>2</sub> laser or cryotherapy in the treatment of solar lentigines and the prevention of eventual posttreatment hyperchromia. <b><i>Methods:</i></b> Efficacy was clinically evaluated by grading the pigmentation level with the Skin Tone Color Scale (STCS), and by grading patients' impression through a Visual Analog Scale (VAS). <b><i>Results:</i></b> Our study shows that the associated treatment was safe and that it improves the therapeutic results on solar lentigines and prevents postiatrogenic hyperpigmentation compared with physical therapy alone. <b><i>Conclusion:</i></b> The combination of cryotherapy and pidobenzone 4% has been found to be the most useful treatment.