Sulfamic Acid: Efficient, Cost-Effective Catalyst for Facile Synthesis of Deazaoxaflavin at Ambient Temperature

A facile, ecofriendly procedure has been developed for the synthesis of substituted 5-deaza-10-oxaflavins by sulfamic acid–catalyzed two-component condensation of salicylaldehyde and barbituric acid at ambient temperature. Mild reaction conditions, short reaction time, ambient temperature, ecofriendly solvent system, wide substrate scope, simple workup procedure, no need for chromatographic separation, and good yields are auxiliary advantages of the present protocol.