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Successful Reorganization of Category-Selective Visual Cortex following Occipito-temporal Lobectomy in Childhood

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posted on 31.07.2018 by Tina Liu, Adrian Nestor, Mark Vida, John Pyles, Christina Patterson, Ying Yang, Fan Nils Yang, Erez Freud, Marlene Behrmann
Investigations of functional (re)organization in children who have undergone large cortical resections offer a unique opportunity to elucidate the nature and extent of cortical plasticity. We report findings from a 3-year investigation of a child, U.D., who underwent surgical removal of the right occipital and posterior temporal lobes at age 6 years 9 months. Relative to controls, post-surgically, U.D. showed age-appropriate intellectual performance and visuoperceptual face and object recognition skills. Using fMRI at five different time points, we observed a persistent hemianopia and no visual field remapping. In category-selective visual cortices, however, object- and scene-selective regions in the intact left hemisphere were stable early on, but regions subserving face and word recognition emerged later and evinced competition for cortical representation. These findings reveal alterations in the selectivity and topography of category-selective regions when confined to a single hemisphere and provide insights into dynamic functional changes in extrastriate cortical architecture.

Funding

This research was supported by NIH grant RO1 EY027018 (to M.B.) and a Presidential Fellowship from Carnegie Mellon University (CMU) (to T.T.L.). Article was published by support from the CMU Article Processing Charge (APC) APC Fund.

History

Publisher Statement

This is the published PDF Version of "Liu, T.T. et al. (2018). Successful Reorganization of Category-Selective Visual Cortex following Occipito-temporal Lobectomy in Childhood. Cell Reports. 24(5). 1113-1122.E6. https://doi.org/10.1016/j.celrep.2018.06.099.

Date

31/07/2018

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