Stereoselective Synthesis of the C1−C13 Fragment of (+)-Discodermolide Using Asymmetric Allyltitanations

The synthesis of the C1−C13 fragment of (+)-discodermolide has been achieved. The configurations of the stereogenic centers have been controlled by enantioselective allyl- and crotyltitanations of aldehydes, and the Z configuration of the olefin at C8−C9 was controlled by a ring-closing metathesis.