ol062465l_si_001.pdf (284.13 kB)
Solid-Phase Synthesis and CD Spectroscopic Investigations of Novel β-Peptides from l-Aspartic Acid and β-Amino-l-alanine
journal contribution
posted on 2007-01-04, 00:00 authored by Sahar Ahmed, Reem Beleid, Tara Sprules, Kamaljit KaurA solid-phase synthesis method for the preparation of novel β3- and β2-peptides derived from l-aspartic acid and β-amino-l-alanine, respectively,
is described. The methodology allows independent buildup of the β-peptide backbone and the introduction of sequential side chain substitutions.
Representative peptides from the two classes, an amino-substituted β3-hexapeptide and an acyl-substituted β2-hexapeptide, have been prepared,
and their solution conformation is studied by circular dichroism (CD) spectroscopy.