Solid-Supported Synthesis of a Peptide
β-Turn Mimetic

Golebiowski, Adam; Klopfenstein, Sean R.; Shao, Xia; Chen, Jack J.; Colson, Anny-Odile; Grieb, Arthur L.; Russell, Anne F.

doi:10.1021/ol006145s.s001

ol006145s_si_001.pdf (269.11 kB)

Solid-Supported Synthesis of a Peptide β-Turn Mimetic

journal contribution

posted on 2000-08-03, 00:00 authored by Adam Golebiowski, Sean R. Klopfenstein, Xia Shao, Jack J. Chen, Anny-Odile Colson, Arthur L. Grieb, Anne F. Russell

The solid-supported synthesis of a bicyclic diketopiperazine, a potential peptide β-turn mimetic, is described. The Ugi reaction between the resin ester of α-N-Boc-diaminopropionic acid (an amine input), α-bromo acid, aldehyde, and isocyanide is the key step in the proposed protocol.