Solid-Supported Synthesis of a Peptide β-Turn Mimetic
2000-08-03T00:00:00Z (GMT) by
The solid-supported synthesis of a bicyclic diketopiperazine, a potential peptide β-turn mimetic, is described. The Ugi reaction between the resin ester of α-<i>N</i>-Boc-diaminopropionic acid (an amine input), α-bromo acid, aldehyde, and isocyanide is the key step in the proposed protocol.
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