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Silicone Pet Tags Associate Tris(1,3-dichloro-2-isopropyl) Phosphate Exposures with Feline Hyperthyroidism
journal contribution
posted on 2019-06-26, 10:45 authored by Carolyn
M. Poutasse, Julie B. Herbstman, Mark E. Peterson, Jana Gordon, Peter H. Soboroff, Darrell Holmes, Dezere Gonzalez, Lane G. Tidwell, Kim A. AndersonFeline hyperthyroidism
is the most commonly diagnosed endocrine-related
disease among senior and geriatric housecats, but the causes remain
unknown. Exposure to endocrine-disrupting compounds with thyroid targets,
such as flame retardants (FRs), may contribute to disease development.
Silicone passive sampling devices, or pet tags, quantitatively assessed
the bioavailable FR exposures of 78 cats (≥7 y) in New York
and Oregon using gas chromatography–mass spectrometry. Pet
tags were analyzed for 36 polybrominated diphenyl ethers, six organophosphate
esters (OPEs), and two alternative brominated FRs. In nonhyperthyroid
cats, serum free thyroxine (fT4), total T4 (TT4), total triiodothyronine, and thyroid-stimulating hormone
concentrations were compared with FR concentrations. Tris(1,3-dichloro-2-isopropyl)
phosphate (TDCIPP) concentrations were higher in hyperthyroid pet
tags in comparison to nonhyperthyroid pet tags (adjusted odds ratio, p < 0.07; Mantel–Cox, p <
0.02). Higher TDCIPP concentrations were associated with air freshener
use in comparison to no use (p < 0.01), residences
built since 2005 compared to those pre-1989 (p <
0.002), and cats preferring to spend time on upholstered furniture
in comparison to no preference (p < 0.05). Higher
TDCIPP concentrations were associated with higher fT4 and
TT4 concentrations (p < 0.05). This
study provides proof-of-concept data for the use of silicone pet tags
with companion animals and further indicates that bioavailable TDCIPP
exposures are associated with feline hyperthyroidism.