Ar431-5.jpg (64.37 kB)
Signal transduction of TNF-α, RANKL and IL-1 in osteoclast differentiation and activation
figure
posted on 2011-12-31, 04:19 authored by Nobuyuki Udagawa, Shigeru Kotake, Naoyuki Kamatani, Naoyuki Takahashi, Tatsuo SudaCopyright information:
Taken from "The molecular mechanism of osteoclastogenesis in rheumatoid arthritis"
Arthritis Research 2002;4(5):281-289.
Published online 12 Apr 2002
PMCID:PMC128939.
Copyright © 2002 BioMed Central Ltd
TNF-α binds TNF receptor type 1 (TNFR1) and TNF receptor type 2 (TNFR2), RANKL binds RANK, and IL-1 binds IL-1 receptor (IL-1R). Both TNFR1 and TNFR2 bind TNF receptor-associated factor 2 (TRAF2), whereas IL-1R binds TNF receptor-associated factor 6 (TRAF6). RANK binds not only TRAF6, but also TRAF2 and other TNF receptor-associated factors (TRAFs). M-CSF, macrophage colony-stimulating factor.