ja6b12949_si_001.pdf (3.35 MB)
Sequence-Selective Binding of Oligopeptides in Water through Hydrophobic Coding
journal contribution
posted on 2017-01-27, 00:00 authored by Joseph
K. Awino, Roshan W. Gunasekara, Yan ZhaoA general
method for sequence-specific binding of peptides remains
elusive despite decades of research. By creating an array of “hydrophobically
coded dimples” on the surface of surface–core doubly
cross-linked micelles, we synthesized water-soluble nanoparticle receptors
to recognize peptides by the location, number, and nature of their
hydrophobic side chains. Minute differences in the side chains could
be distinguished, and affinities up to 20 nM were obtained for biologically
active oligopeptides in water.