Sensitivity of neurofibroma and MPNST cell lines to doxorubucin.

(A) An in vitro cytotoxicity assay (SRB assay) was used to determine IC₅₀ values (ng/ml) for doxorubucin of neurofibroma and MPNST cell lines after a 48h exposure to the drug. Graphs show cell viability as a function of doxorubucin concentration. Depicted is the average viability (n = 4) of a representative experiment. (B) Listing of calculated IC₅₀ values and correlation plot, with TOP2A protein expression levels on the Y-axis and IC₅₀ values for doxorubicin on the X-axis. Pearson correlation coefficient is depicted in the graph.