ol7b00726_si_001.pdf (5.02 MB)
Selective Phosphoramidation and Phosphonation of Benzoxazoles via Sequence Control
journal contribution
posted on 2017-04-21, 12:34 authored by Ling Huang, Jiuhan Gong, Zheng Zhu, Yufeng Wang, Shengmei Guo, Hu CaiA selective
phosphoramidation and phosphonation of benzoxazole
was developed with trialkyl phosphites in the presence of iodine under
mild conditions. In the reaction, the transformation completes in
10 min at room temperature and the substrates are well tolerant, as
2-substituted azoles could afford the quaternary carbon-centered products.
Significantly, phosphites could be selectively introduced into the
C- and N-positions of the benzoxazoles by controlling the addition
sequence and the ratio of substrates.