Fig 6.tif (5.61 MB)
STORM images of MCF7 expressing the ErbB2-TagRFP fusion protein and SKBR3 cells.
figure
posted on 2017-03-17, 17:29 authored by Andrés Martín Toscani, Rocío G. Sampayo, Federico Martín Barabas, Federico Fuentes, Marina Simian, Federico Coluccio LeskowCells were labeled with a specific antibody for ErbB2 (OP15, Millipore) and a secondary antibody coupled with the Alexa Fluor 647 fluorophore. It was possible to determine the presence of two different receptor populations: one inside the clusters and another outside these structures, seen as small spots, representing monomers or low stoichiometry aggregates of ErbB2.
History
Usage metrics
Categories
Keywords
breast cancer cellsErbB 2 overexpressionErbB 2 membrane domainsextracellular matrix proteins shape membrane clusters distributionextracellular matrix proteinsDistinct ErbB 2 receptor populations differentiallyplasma membraneErbB 2beta 1 integrinErbB 2 formstyrosine kinase receptorsErbB 2 colocalizationbreast cancer cell models ErbB 2beta 1 integrin activityexpression levelsbreast cancer progression
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC