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SPR binding profiles of anti-FGFR2 scFvF7 and anti-FGFR1 scFvC1 to FGFRs.

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posted on 2018-02-08, 18:45 authored by Aleksandra Borek, Aleksandra Sokolowska-Wedzina, Grzegorz Chodaczek, Jacek Otlewski

Binding of scFvs to (a) ECD_FGFR1-Fc, (b) ECD_FGFR2-Fc, (c) ECD_FGFR3-Fc, (d) ECD_FGFR4-Fc and (e) Fc. Clone scFvC1 was selected against ECD_FGFR1 [27] and was used as a negative control.

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    FGFR 2-positive tumor cellsaffinityNCI-HscFvF 7-Fc antibodyMMAEfragment scFv phage display libraries Tomlinsonextracellular ligand-binding domaininternalizing anti-FGFR 2 single-chainECDcytotoxic drug monomethyl-auristatin EFGF receptor 2bivalent diabody formatFGFR 2cancers Fibroblast growth factor receptorsnanomolar K D valuesscFvF 7-FcFGFR 2 overexpressionphage display technology

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