Review protocol celiac disease and enamel defects.docx (85.37 kB)
Review protocol celiac disease and enamel defects.docx
Protocol for a systematic review and meta-analysis
Title of the systematic Review:
Enamel defects and aphtous stomatitis in celiac patients and normal controls: systematic review and meta-analysis of controlled studies
Review question
Comparison of enamel defects and aphtous stomatitis between celiac patients and healthy controls
Searches
3 electronic databases were serched: PubMed, Embase, and Google Scholar. Grey iterature was serached on OpenGray. Manual serach was performed in the following journals starting from Jan 1990: European Journal of Paediatric Dentistry, Pediatric Dentistry, Community dentistry and oral epidemiology, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, Journal of pediatric gastroenterology and nutrition, Gastroenterology, The American journal of gastroenterology, Journal of gastroenterology, Journal of dental research.
Participants/population
Children (up to 18 years) and adults with celiac disease compared to healthy individuals
Intervention(s), exposure(s)
Patients with celiac disease
Comparator(s)/control
Healthy individuals
Types of study to be included
Controlled studies (cohort, cross-sectional, and case control studies)
Primary outcome(s)
Presence/absence of enamel defects and presence/absence of aphtous stomatitis
Risk of bias (quality) assessment
Presence of a blinded examiner Comparability of age and gender between the celiac patients and healthy individuals
Strategy for data synthesis
The Mantel-Haenszel with random effects using odds ratio will be applied.
Analysis of subgroups or subsets
Children and adults
Title of the systematic Review:
Enamel defects and aphtous stomatitis in celiac patients and normal controls: systematic review and meta-analysis of controlled studies
Review question
Comparison of enamel defects and aphtous stomatitis between celiac patients and healthy controls
Searches
3 electronic databases were serched: PubMed, Embase, and Google Scholar. Grey iterature was serached on OpenGray. Manual serach was performed in the following journals starting from Jan 1990: European Journal of Paediatric Dentistry, Pediatric Dentistry, Community dentistry and oral epidemiology, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, Journal of pediatric gastroenterology and nutrition, Gastroenterology, The American journal of gastroenterology, Journal of gastroenterology, Journal of dental research.
Participants/population
Children (up to 18 years) and adults with celiac disease compared to healthy individuals
Intervention(s), exposure(s)
Patients with celiac disease
Comparator(s)/control
Healthy individuals
Types of study to be included
Controlled studies (cohort, cross-sectional, and case control studies)
Primary outcome(s)
Presence/absence of enamel defects and presence/absence of aphtous stomatitis
Risk of bias (quality) assessment
Presence of a blinded examiner Comparability of age and gender between the celiac patients and healthy individuals
Strategy for data synthesis
The Mantel-Haenszel with random effects using odds ratio will be applied.
Analysis of subgroups or subsets
Children and adults
