Review protocol celiac disease and enamel defects.docx

2017-02-17T16:18:42Z (GMT) by Lorenzo Franchi
Protocol for a systematic review and meta-analysis <br><br>
Title of the systematic Review:<br>Enamel defects and aphtous stomatitis in celiac patients and normal controls: systematic review and meta-analysis of controlled studies<br><br>Review question<br>Comparison of enamel defects and aphtous stomatitis between celiac patients and healthy controls<br><br>Searches<br>3 electronic databases were serched: PubMed, Embase, and Google Scholar. Grey iterature was serached on OpenGray. Manual serach was performed in the following journals starting from Jan 1990: European Journal of Paediatric Dentistry, Pediatric Dentistry, Community dentistry and oral epidemiology, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, Journal of pediatric gastroenterology and nutrition, Gastroenterology, The American journal of gastroenterology, Journal of gastroenterology, Journal of dental research.<br><br>Participants/population<br>Children (up to 18 years) and adults with celiac disease compared to healthy individuals<br><br>Intervention(s), exposure(s)<br>Patients with celiac disease<br> <br>Comparator(s)/control<br>Healthy individuals<br><br>Types of study to be included<br>Controlled studies (cohort, cross-sectional, and case control studies)<br><br>Primary outcome(s)<br>Presence/absence of enamel defects and presence/absence of aphtous stomatitis<br><br>Risk of bias (quality) assessment<br>Presence of a blinded examiner Comparability of age and gender between the celiac patients and healthy individuals<br><br>Strategy for data synthesis<br>The Mantel-Haenszel with random effects using odds ratio will be applied.<br><br>Analysis of subgroups or subsets<br>Children and adults<br>