Reductive Cross-Coupling of 3‑Bromo-2,1-borazaronaphthalenes
with Alkyl Iodides

Molander, Gary A.; Wisniewski, Steven R.; Traister, Kaitlin M.

doi:10.1021/ol501495d.s001

ol501495d_si_001.pdf (2.1 MB)

Reductive Cross-Coupling of 3‑Bromo-2,1-borazaronaphthalenes with Alkyl Iodides

journal contribution

posted on 2015-12-17, 03:20 authored by Gary A. Molander, Steven R. Wisniewski, Kaitlin M. Traister

Conditions have been developed for the reductive cross-coupling of 3-bromo-2,1-borazaronaphthalenes with primary and secondary alkyl iodides. This method allows direct alkylation of azaborine cores, providing efficient access to functionalized isosteres of naphthalene derivatives.