ma502003v_si_001.pdf (1.34 MB)
Quadruple-Stimuli-Sensitive Polymeric Nanocarriers for Controlled Release under Combined Stimulation
journal contribution
posted on 2014-12-23, 00:00 authored by Ziquan Cao, Hao Wu, Jie Dong, Guojie WangHere
we report a novel quadruple-stimuli-responsive block copolymer nanocarrier
sensitive to pH, temperature, light, and reducing agent. The well-defined
amphiphilic diblock copolymer poly(2-nitrobenzyl methacrylate)-SS-poly(dimethylaminoethyl
methacrylate) (PNBM-SS-PDMAEMA) was synthesized via two steps of atom
transfer radical polymerization (ATRP). In aqueous solution, the diblock
copolymer self-assembled into nanoparticles consisting of a light-responsive
hydrophobic PNBM core, a pH- and temperature-responsive hydrophilic
PDMAEMA corona, and a redox-sensitive disulfide linker. The multi-stimuli-responsive
behaviors of the block copolymer assemblies were revealed by transmission
electron microscopy (TEM) and dynamic light scattering (DLS). The
release of encapsulated molecules from the polymeric nanocarriers
could be enhanced under combined stimulation. The prepared multi-stimuli-responsive
nanocarriers may offer significant opportunities in diverse applications
in the fields of nanotechnology and biotechnology for controlled release.