Procaspase 8 inducing drugs in acute <i>in vitro</i> HIV infection model.

<p><b>A)</b> Primary uninfected CD4 cells from 3 donors were infected with HIV IIIB and then incubated with procaspase 8 inducing drugs for 48hours with RAL and TDF. ATP, HIV DNA by qPCR <b>(B)</b>, and supernatant P24 <b>(D)</b> were assessed. <b>C)</b> The degree of procaspase 8 expression induction by ELISA was compared between drugs which reduced HIV DNA or did not reduce HIV DNA in panel (B). Depicted are means (SD). E) Pearson correlation coefficient between the change in cell associated HIV DNA and change in supernatant p24 was assessed.</p>