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Preservation of strain specific PrPSc migration following PMCA.

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posted on 2018-10-18, 18:08 authored by Thomas E. Eckland, Ronald A. Shikiya, Jason C. Bartz

Western blot analysis (A) and PrPSc migration analysis (B) of PK digested brain material from hamsters inoculated with either 10th serial round PMCA reactions seeded with uninfected (UN) brain homogenate, DY, 139H or an equal mixture of DY and 139H-infected brain homogenate.

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    PLOS Pathogens

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    prion conversion efficiencylong-incubation period strainsPrion strain interference influences prion strain dynamicsshort-incubation period strainPrP Cprion strainsstrain interferenceprotein misfolding cyclic amplification strain interferenceconversion efficiency prion strains Prion diseasesImportantly PMCA reactionsanimal bioassay studieslong-incubation period strainPrP Sc

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