posted on 2006-06-22, 00:00authored byScott D. Rychnovsky
The structure of the natural product hexacyclinol was reassigned from endoperoxide 1 to the diepoxide 7 on the basis of calculated 13C
chemical shift data using HF/3-21G geometries and mPW1PW91/6-31G(d,p) GIAO NMR predictions. These predictions correlate very well with
experimental data for three other highly oxygenated natural products, elisapterosin B, maoecrystal V, and elisabethin A. Hexacyclinol is
proposed to arise from acid-catalyzed rearrangement of panepophenanthrin in the presence of methanol.