ja5107578_si_001.pdf (550.19 kB)
Potentiometric Response from Ion-Selective Nanospheres with Voltage-Sensitive Dyes
journal contribution
posted on 2015-12-17, 06:04 authored by Xiaojiang Xie, Jingying Zhai, Eric BakkerPotentiometric
sensors require the implementation of conducting
wires for signal transduction, but this is impractical for the readout
of individual nanoparticles. It is here demonstrated for the first
time that the potentiometric response of ion-selective nanospheres
can be observed with voltage-sensitive dyes, thereby converting nanoscale
electrochemical signals into an optical readout. No reference electrode
is needed since the readout is by fluorescence. The results strongly
support the potentiometric origin for the fluorescence response. The
ion-selective nanospheres exhibit excellent selectivity and respond
to ion concentration changes independent of sample pH, providing a
new platform of potentiometric nanosensors with optical readout compatible
with optical imaging equipment.