Polygonumnolides C1-C4; minor dianthrone glycosides from the roots of Polygonum multiflorum Thunb

Four new dianthrone glycosides, named polygonumnolides C1-C4 (1–4), were isolated from the dried roots of Polygonum multiflorum Thunb, together with two known emodin dianthrones (5–6). Their hepatotoxicities were evaluated against L-02 cell lines. Compounds 1–4 showed weak hepatotoxicity against L-02 cell lines with IC₅₀ values of 313.05, 205.20, 294.20, and 207.35 μM, respectively.