Fig 9.TIF (1.17 MB)
Plasma membrane/cilium-localized Gish/CK1γ modulates Hh signaling by phosphorylating Smo.
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posted on 2016-06-09, 06:15 authored by Shuangxi Li, Shuang Li, Yuhong Han, Chao Tong, Bing Wang, Yongbin Chen, Jin JiangHh stimulates cell surface/ciliary accumulation of Smo, which facilitates its association, phosphorylation, and activation by Gish/CK1γ. In Drosophila, Hh morphogen gradient generates increasing levels of Smo activity by differential regulation of PKA/CK1- and Gish-mediated phosphorylation of Smo. See text for details.
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Smo phosphorylationHh morphogenjuxtamembrane regionprotein kinaseSmo subcellular localizationPlasma Membrane Associated Kinase HedgehogPKAactivates SmoSmoothened Phosphorylationplasma membraneadult tissue homeostasiscell surface localizationSonic hedgehogcell surfaceG proteinpathway activationGPCRCK 1γ
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