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Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway - Fig 2
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posted on 2017-02-17, 18:51 authored by Wafa Zeriouh, Abdelhafid Nani, Meriem Belarbi, Adélie Dumont, Charlotte de Rosny, Ikram Aboura, Fatima Zahra Ghanemi, Babar Murtaza, Danish Patoli, Charles Thomas, Lionel Apetoh, Cédric Rébé, Dominique Delmas, Naim Akhtar Khan, François Ghiringhelli, Mickael Rialland, Aziz HichamiEffects of PEOL on the viability and morphology of HCT116 (A), HCT8 (B), and CCD 841 CoN cells (C). The cells (6 ×103 cells/well) were incubated with different concentrations of PEOL for 24 h as described in Materials and Methods. Cell viability was measured by MTT test and morphology was assessed by light microscopy (magnification ×200). *,**,*** represent p < 0.05, p < 0.01, p < 0.001 respectively as compared to untreated cells. p values were obtained by one-way ANOVA, followed by Fisher’s LSD test.
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PEOL-induced cell deathcolon cancer cell linescolon cancer cellsROS-induced endoplasmic reticulumcolon cancer growthOlea europaea varHCT 116HCT 116 tumor growthERHCT 8 cellscytochrome c releasecolon cancer cell linereactive oxygen speciesPEOL-induced ROS generationmitochondrial apoptotic pathwayapoptosioleaster leaf infusionCRC cell linesBAPTAapoptotic effectoleaster leaf polyphenol-rich infusionmitochondrial calcium uptake
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