ol7b02114_si_001.pdf (1.8 MB)
Pd-Catalyzed Thiophene–Aryl Coupling Reaction via C–H Bond Activation in Deep Eutectic Solvents
journal contribution
posted on 2017-09-06, 16:05 authored by Angela Punzi, Donato I. Coppi, Sergio Matera, Maria A. M. Capozzi, Alessandra Operamolla, Roberta Ragni, Francesco Babudri, Gianluca M. FarinolaDirect
arylation of 5-octylthieno[3,4-c]pyrrole-4,6-dione
with a series of functionalized aryl iodides via C–H bond activation
is demonstrated in a deep eutectic solvent made of choline chloride
and urea in non-anhydrous conditions and without exclusion of air.
This is the first demonstration of a thiophene–aryl coupling
via direct arylation in deep eutectic solvents.