Pd-Catalyzed Thiophene–Aryl Coupling Reaction via C–H Bond Activation in Deep Eutectic Solvents

Direct arylation of 5-octylthieno­[3,4-<i>c</i>]­pyrrole-4,6-dione with a series of functionalized aryl iodides via C–H bond activation is demonstrated in a deep eutectic solvent made of choline chloride and urea in non-anhydrous conditions and without exclusion of air. This is the first demonstration of a thiophene–aryl coupling via direct arylation in deep eutectic solvents.