Palladium catalyzed Heck reaction of 2-iodoanilines under ligand-free conditions in air

Chen, Xia; Zhou, Xiao-Yu; Wang, Liang-Guang

doi:10.6084/m9.figshare.5330506

lsyc_a_1365905_sm7952.doc (2.52 MB)

Palladium catalyzed Heck reaction of 2-iodoanilines under ligand-free conditions in air

Version 2 2017-10-19, 19:55

Version 1 2017-08-21, 18:42

journal contribution

posted on 2017-10-19, 19:55 authored by Xia Chen, Xiao-Yu Zhou, Liang-Guang Wang

Palladium catalyzed Heck reaction of 2-iodoanilines and acrylate has been developed. The palladium catalyzed Heck reaction of 2-iodoanilines can readily occur in CH₃CN using Pd(OAc)₂ (5.0 mol%) as catalyst, NEt₃ as base under ligand-free conditions. And 2-alkenylanilines were obtained as the cross-coupling products with medium to high yield.