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Palladium(II)-Catalyzed Three-Component Coupling Reaction Initiated by Acetoxypalladation of Alkynes: An Efficient Route to γ,δ-Unsaturated Carbonyls
journal contribution
posted on 2002-09-26, 00:00 authored by Ligang Zhao, Xiyan LuA divalent palladium-catalyzed coupling reaction of electron-deficient alkynes and acrolein or MVK (methyl vinyl ketone) was developed. The
reaction provides an efficient method to synthesize γ,δ-unsaturated carbonyls. A mechanism involving acetoxypalladation of alkyne, followed
by insertion of alkene and protonolysis of the C−Pd bond, is proposed. The protonolysis of the carbon−palladium bond with the assistance
of bidentate nitrogen containing ligands is the key step in this tandem reaction.