ol2024339_si_001.pdf (985.14 kB)
Palladium-Catalyzed 1,4-Addition of Diarylphosphines to α,β-Unsaturated Aldehydes
journal contribution
posted on 2016-02-22, 17:18 authored by Yun-Rong Chen, Wei-Liang DuanA highly stereoselective asymmetric 1,4-addition of diarylphosphines to α,β-unsaturated aldehydes catalyzed by a bis(phosphine) pincer–Pd complex has been developed for the synthesis of chiral phosphines with excellent stereoselectivity (up to 98% ee) under mild conditions. The application of the current method to the synthesis of enantiopure bisphosphine and its pincer–Pd complex has also been demonstrated.