ol6b03310_si_001.pdf (1.99 MB)
Palladium-Catalyzed Tandem C–H Functionalization/Cyclization Strategy for the Synthesis of 5‑Hydroxybenzofuran Derivatives
journal contribution
posted on 2016-12-13, 16:06 authored by Sachin
S. Ichake, Ashok Konala, Veerababurao Kavala, Chun-Wei Kuo, Ching-Fa YaoA palladium-catalyzed
benzoquinone C–H functionalization/cyclization
strategy with terminal alkynes was employed for the synthesis of some
biologically relevant 2,3-disubstituted 5-hydroxybenzofuran derivatives.
The benzoquinone acts as a reactant as well as an oxidant. During
the process, an additional alkyne functionality can be introduced
at the C3 position of the benzofuran. Base, ligand, and external oxidant
are not required in this protocol.