Fig 4.TIF (448.49 kB)
PK profile of castanospermine (semi-log plot).
figure
posted on 2016-08-10, 17:30 authored by Cynthia Sung, Yuan Wei, Satoru Watanabe, How Sung Lee, Yok Moi Khoo, Lu Fan, Abhay P. S. Rathore, Kitti Wing-Ki Chan, Milly M. Choy, Uma S. Kamaraj, October M. Sessions, Pauline Aw, Paola F. de Sessions, Bernett Lee, John E. Connolly, Martin L. Hibberd, Dhanasekaran Vijaykrishna, Limin Wijaya, Eng Eong Ooi, Jenny Guek-Hong Low, Subhash G. VasudevanSolid brown line is the predicted concentration of castanospermine based on the mean PK parameters and the dosing regimen studied in the trial. Gray open circles are the observed peak and trough concentrations of castanospermine. Symbols and error bars are the mean and SEM, respectively. Black dotted line is the target trough concentration (400 ng/mL) predicted based on animal efficacy studies.
