Fig 4.tif (1.15 MB)
PI3K/Akt signaling is involved in GSK-3β inhibition.
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posted on 2016-12-15, 19:04 authored by Javier Duran, Cesar Oyarce, Mario Pavez, Denisse Valladares, Carla Basualto-Alarcon, Daniel Lagos, Genaro Barrientos, Mayarling Francisca Troncoso, Cristian Ibarra, Manuel EstradaCardiac myocytes were pretreated for 30 min with Akt-inhibitor VIII (Akti-VIII, 10 μM), LY-294002 (10 μM), or PD98059 (50 μM) prior to testosterone stimulation (100 nM) by 30 min. The densitometry results show the ratio of phosphorylated protein to total protein (n = 4 for each condition). Values are presented as the mean ± SEM. *p < 0.05 vs. control.
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GSK -3β phosphorylationGSK -3βThr 41. GSK -3β inhibitionβ- catenin protein accumulationGSK -3βSglycogen synthase kinase -3βcalcineurin inhibitors FK 506NFAT-Luc activityβ- catenin phosphorylationGSK -3β activationmyocyte hypertrophyintracellular androgen receptorTestosterone-Induced Cardiac Myocyte Hypertrophy Testosterone100 nM testosteroneGSK -3β activityR-VIVITtestosterone-induced NFAT-Luc activationmodulating NFAT activityGSK -3β-targeting siRNAGSK -3β inhibition
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