One-Pot Synthesis of Benzothiazole-Tethered Chromanones/Coumarins via Claisen Rearrangement Using the Solid State Melt Reaction

2016-03-18T00:00:00Z (GMT) by Manickam Bakthadoss Raman Selvakumar
A novel protocol has been successfully established for the efficient synthesis of benzothiazole-tethered chromanone/coumarin scaffolds via Claisen rearrangement using a solid state melt reaction in a one-pot manner. Benzothiazole formation and Claisen rearrangement involve the cleavage of S–S and C–O bonds and formation of C–S, CN, and C–C bonds in a single operation without using a catalyst or solvent.