One-pot PEG-mediated syntheses of 2-(2-hydrazinyl) thiazole derivatives: novel route

2017-09-12T09:30:39Z (GMT) by Dattatraya G. Raut Raghunath B. Bhosale
<p>Thiazoles are important sulfur-containing molecules that are widely used in diverse fields such as pharmaceuticals, agrochemicals, and material sciences. This is the first report on the PEG-300-mediated one-pot synthesis of 2-(2-hydrazinyl) thiazole derivatives from ketones, thiosemicarbazide, and α-halo ketones. Here PEG-300 acts as a solvent as well as supporting catalyst. Formation of compounds was confirmed by IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and mass spectroscopic studies.</p> <p>A series of 2-(2-hydrazinyl) Thiazole derivatives have been synthesized from substituted ketones, thiosemicarbazide & α-halo ketones using PEG-300 as a reaction medium via one-pot approach.</p>