ppat.1006124.g001.tif (8.86 MB)

Nuclear localization of STAT6 occurs in KS patient tissues.

figure

posted on 2017-01-18, 04:30 authored by Chong Wang, Caixia Zhu, Fang Wei, Shujun Gao, Liming Zhang, Yuhong Li, Yanling Feng, Yin Tong, Jianqing Xu, Bin Wang, Zhenghong Yuan, Erle S. Robertson, Qiliang Cai

(A) Representative images of immunohistochemistry staining against STAT6 in KS patient tissue and normal skin tissue. The larger magnification (x400) image and relative percentage of staining cells with STAT6 nuclear localization (Arrow) is shown in the lower panels. (B) The relative percentage of STAT6 nuclear localization from panel A was individually quantified by nuclear and cytoplasmic staining of 100 cells. Asterisks indicate P<0.05. (C) Immunofluorescent analysis of endogenous STAT6, LANA and merged in KS patient tissue and normal skin tissue. Nuclei were stained with DAPI. Scale bars represent 50μM. (D) The relative percentage of STAT6 nuclear localization in the presence of LANA from panel C was individually quantified by nuclear and cytoplasmic staining of 100 cells.