Norbornene-based anion receptors as D-alanine binders

2015-11-26T20:33:17Z (GMT) by Benjamin M. Long Frederick M. Pfeffer
<div><p>Vancomycin is currently used as last-line therapy against many Gram-positive bacterial pathogens. Herein, we report a series of peptidomimetic norbornene-based anion receptors that were designed as simple vancomycin mimics New hosts were evaluated for their affinity to both acetate and acetyl D-Ala by <sup>1</sup>H NMR titration. Modest binding to both anions was observed in DMSO-<i>d</i><sub>6</sub> (Log K<sub>a</sub> 1–2 for TBA Acetyl D-Alanine) in the anticipated 1:1 mode of binding.</p></div>