np7b00947_si_002.pdf (16.31 MB)
Nitric Oxide Inhibitory Sesquiterpenoids and Its Dimers from Artemisia freyniana
journal contribution
posted on 2018-03-08, 18:50 authored by Chen Zhang, Ran Wen, Xiao-Li Ma, Ke-Wu Zeng, Yang Xue, Pu-Ming Zhang, Ming-Bo Zhao, Yong Jiang, Guo-Qing Liu, Peng-Fei TuTwo new disesquiterpenoids (1 and 2)
and 11 new (3–13) and 10 known (14–23) sesquiterpenoids were isolated
from the whole plants of Artemisia freyniana. Their
structures were elucidated by spectroscopic data analysis and comparison
with published NMR data. The absolute configurations of the new isolates
(1–13) were assigned based on single-crystal
X-ray diffraction data and comparison of the experimental and calculated
ECD data. The eremophilane derivatives 8 and 9 possess an unprecedented 2-isopropyl-3,7,7a-trimethyl-2,4,5,6,7,7a-hexahydro-1H-indene scaffold, and a putative biosynthetic pathway for
these compounds is proposed. Compounds 4, 5, and 9 exhibited inhibitory effects against LPS-stimulated
nitric oxide (NO) production in RAW 264.7 macrophage cells with IC50 values of 10.8, 12.6, and 11.7 μM, respectively.