New cytotoxic constituents from the Red Sea soft coral Nephthea sp.

Hegazy, Mohamed-Elamir F.; M. Gamal-Eldeen, Amira; Mohamed, Tarik A.; A. Alhammady, Montaser; A. Hassanien, Abuzeid; A. Shreadah, Mohamed; I. Abdelgawad, Ibrahim; M. Elkady, Eman; W. Paré, Paul

doi:10.6084/m9.figshare.1480647

gnpl_a_1055266_sm4485.pdf (1.27 MB)

New cytotoxic constituents from the Red Sea soft coral Nephthea sp.

journal contribution

posted on 2015-07-06, 00:00 authored by Mohamed-Elamir F. Hegazy, Amira M. Gamal-Eldeen, Tarik A. Mohamed, Montaser A. Alhammady, Abuzeid A. Hassanien, Mohamed A. Shreadah, Ibrahim I. Abdelgawad, Eman M. Elkady, Paul W. Paré

Nephthea are soft coral species rich in sesquiterpenoids and steroids. An organic extract of Nephthea sp. resulted in the isolation of a new steroid (1), as well as several previously reported metabolites (2–9). Structures were elucidated by employing NMR and HR-EI-MS analyses. The total extract, fractions and purified compounds exhibited differential cytotoxicity against the breast cancer MCF-7 cell line.