New Route to Azaspirocycles via the
Organolithium-Mediated Conversion of
β-Alkoxy Aziridines into Cyclopentenyl
Amines

Moore, Stephen P.; Coote, Susannah C.; O'Brien, Peter; Gilday, John

doi:10.1021/ol062073e.s001

ol062073e_si_001.pdf (491.94 kB)

New Route to Azaspirocycles via the Organolithium-Mediated Conversion of β-Alkoxy Aziridines into Cyclopentenyl Amines

journal contribution

posted on 2006-10-26, 00:00 authored by Stephen P. Moore, Susannah C. Coote, Peter O'Brien, John Gilday

A new three-step route to azaspirocycles involving the organolithium-mediated conversion of β-alkoxy aziridines into substituted cyclopentenyl amines, hydroboration, and cyclization has been developed. The methodology is utilized in the construction of the pentacyclic ring system of cephalotaxine.