New C<sub>20</sub>-gibberellin diterpene from the leaves of <i>Schefflera sessiliflora</i> De P. V.

<div><p>From the leaves of <i>Schefflera sessiliflora</i> De P. V., one new C<sub>20</sub>-gibberellin diterpene 2β,12β-dihydroxygibberellin (12β-hydroxy-GA<sub>110</sub> or 2β-hydroxy-GA<sub>112</sub>) (<b>1</b>), together with three known compounds, <i>trans</i>-tiliroside (<b>2</b>), kaempferol 3-<i>O</i>-β-d-glucuronopyranoside (<b>3</b>), 5-<i>p</i>-<i>trans</i>-coumaroylquinic acid (<b>4</b>), was isolated for the first time from the genus <i>Schefflera</i> by various chromatography methods. Their structures were elucidated by IR, UV, HR-ESI-MS, NMR 1D and 2D experiments and comparison with previous reported data. The α-glucosidase inhibitory activity of all compounds was measured. The isolates (<b>2</b>, <b>3</b>) showed better α-glucosidase inhibitory activity (IC<sub>50</sub> = 134.60, 147.10 μM, respectively) than the standard drug acarbose (IC<sub>50</sub> = 214.50 μM).</p></div>