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Neutralization of heterologous Tier-1 viruses.

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posted on 2016-09-14, 04:30 authored by P. J. Klasse, Celia C. LaBranche, Thomas J. Ketas, Gabriel Ozorowski, Albert Cupo, Pavel Pugach, Rajesh P. Ringe, Michael Golabek, Marit J. van Gils, Miklos Guttman, Kelly K. Lee, Ian A. Wilson, Salvatore T. Butera, Andrew B. Ward, David C. Montefiori, Rogier W. Sanders, John P. Moore

The arithmetic mean neutralization titers (IC50) against the Env-pseudotyped Tier-1 viruses MN.3 (clade B) and MW965.26 (clade C), derived at DUMC, are plotted over time for the rabbit groups denoted by the key to the right.

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    PLOS Pathogens

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    SOSIP .664 trimersB trimersclade B trimers73- week periodEnvelope Glycoprotein SOSIP .664 TrimersCZA 97 trimersBG 505.T virusclade C trimersimmunodeficiency virus type 1clade CTier -2 neutralizing antibodyDU 422 trimersheterologous Tier -2 NAb responsesneutralizing antibody responsesHIVautologous Tier -2 NAb responses

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