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Nesteretal A, A Novel Class of Cage-Like Polyketide from Marine-Derived Actinomycete Nesterenkonia halobia
journal contribution
posted on 2019-08-17, 18:13 authored by Chun-Lan Xie, Renzhi Chen, Sihan Yang, Jin-Mei Xia, Gai-Yun Zhang, Chao-Hong Chen, Yandong Zhang, Xian-Wen YangAn intriguing cage-like
polyhemiketal, nesteretal A (1), was isolated from the
coral-derived actinomycete Nesterenkonia halobia.
Its structure was established by extensive spectroscopic and computational
methods. Nesteretal A is a highly oxygenated compound featuring an
unprecedented 5/5/5/5 tetracyclic scaffold. A possible biosynthetic
pathway of 1 from naturally occurring diacetyl was proposed.
Compound 1 showed a weak retinoid X receptor-α
(RXRα) transcriptional activation effect.
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retinoid X receptor -αtranscriptionalCage-Like PolyketideNovel ClassNesteretalcoral-derived actinomycete Nesterenkonia halobiadiacetylscaffoldnesteretalactivationspectroscopicoxygenated compoundcage-like polyhemiketalbiosynthetic pathwayRXRCompound 1tetracyclicmethodMarine-Derived Actinomycete Nesterenkonia halobia
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