np7b00188_si_002.cif (18.62 kB)
Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense
dataset
posted on 2017-06-02, 20:17 authored by Mohammad Nur-e-Alam, Muhammad Yousaf, Sarfaraz Ahmed, Ebtesam S. Al-Sheddi, Ifat Parveen, David M. Fazakerley, Ahmed Bari, Hazem A. Ghabbour, Michael D. Threadgill, Kezia C. L. Whatley, Karl F. Hoffmann, Adnan J. Al-RehailyTeucrium yemense (Defl), locally known as Reehal
Fatima, is a medicinal plant commonly grown in Saudi Arabia and Yemen.
Phytochemical investigation of the aerial parts of T. yemense yielded six new neoclerodane diterpenoids, namely fatimanol A–E
(1, 2, 3, 5, and 6) and fatimanone (4), and the known teulepicephin
(7). As both the Teucrium genus and
the related Lamiaceae family have previously been
widely reported to possess anthelmintic and antimicrobial activities,
the structural and biological characterization of the seven diterpenoids
was pursued. The structures of the new compounds were elucidated from
their 2D NMR and MS profiles and by comparison to related compounds.
The structure of fatimanol D (5) was confirmed by X-ray
crystallographic analysis. The new structures contribute to the breadth
of knowledge of secondary metabolites in this genus.
