rsif20170512_si_006.m4v (1.76 MB)
Movie M5 from Numb prevents a complete epithelial–mesenchymal transition by modulating Notch signalling
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posted on 2017-11-16, 13:51 authored by Federico Bocci, Mohit Kumar Jolly, Satyendra C. Tripathi, Mitzi Aguilar, Samir M. Hanash, Herbert Levine, José N. OnuchicTemporal dynamics of the cell phenotype distribution (green: epithelial, yellow: hybrid E/M, red: mesenchymal) over 120 hours for the 50x50 layer of cells in the Control case (no Numb) and with Notch-Delta signalling. The final configuration of this simulation (120 hours) corresponds to the distribution presented in Fig. S9a. For this simulation, the parameters are the same of Fig. S9a.